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Lupus Leads Inflammatory Disorders in Cardiometabolic Risk

Lupus Leads Inflammatory Disorders in Cardiometabolic Risk

The risk of cardiometabolic events is high in inflammatory disorders, especially systemic lupus erythematosus, a recent study showed. The events may vary by anti-inflammatory therapy and duration.

All-cause mortality also was higher in patients who had systemic lupus erythematosus or another specific inflammatory disorder than in those who had no inflammatory disorder.

The relationship between inflammatory disorders with cardiometabolic diseases and mortality within a community-based population was assessed by researchers at King’s College London, London, and the National Institute for Health Research Biomedical Research Centre, Guy’s and St Thomas NHS Foundation Trust, also in London.

They used UK Biobank data to conduct a cross-sectional study to estimate cardiometabolic risk and a prospective cohort study to estimate mortality risk.

Binary regression analyses helped model the association between coronary heart disease, stroke, type 2 diabetes, venous thromboembolism, and peripheral artery disease diagnoses with the following inflammatory disorders: rheumatoid arthritis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, systemic vasculitis, Crohn disease, and ulcerative colitis.

The researchers reported their findings in Heart.

Some key points:

Multiple cardiometabolic diseases were more common among systemic lupus erythematosus and vasculitis disorders and less common with Crohn disease and psoriasis disorders.

Participants with a diagnosis of systemic lupus erythematosus presented the highest rates of cardiometabolic events, except for type 2 diabetes, which was more common among participants reporting rheumatoid arthritis, vasculitis, or psoriasis disorders.

Patients with a systemic lupus erythematosus diagnosis presented a 6-fold adjusted increased risk of multiple cardiometabolic events.

Systemic lupus erythematosus showed the strongest association with multiple risk of cardiometabolic diseases, followed by rheumatoid arthritis, ulcerative colitis, ankylosing spondylitis, vasculitis, and psoriasis.

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