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Review in Brief: Lupus and Thrombosis

Review in Brief: Lupus and Thrombosis

  • lupus
    These slides summarize the following systematic review of managing and treating thrombosis risk in lupus: Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • lupus
    SLE is a risk factor for both arterial and thrombotic events, a fact not included in diagnostic criteria. Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • lupus
    Thrombotic events are strongly associated with antiphospholipid antibodies. Not all SLE patients have antiphospholipid antibodies, and vice versa. Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • antiphospholipid syndrome
    Three laboratory tests define antiphospholipid syndrome Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • lupus
    Three positive tests for antiphospholipid syndrome indicates the strongest prognostic value for thrombosis in patients with lupus. But clinical factors are also important. Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • lupus
    Clinical criteria for antiphospholipid syndrome include prior thrombotic events and pregnancy losses. Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • lupus
    About half of SLE patients die from cardiovascular causes, strongly linked to inflammatory and immunological mechanisms. Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • lupus
    Other clinical risk factors include retinal vein occlusion, lupus nephropathy, and infectious episodes. All SLE patients are at higher risk during active phases of the disease. Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • lupus
    Higher intensity and sometimes long-term anticoagulation therapy are recommended for patients with antiphospholipid syndrome who have experienced thrombotic events. Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • lupus
    Low-dose aspirin or heparin prophylaxis is recommended for some patients with antiphospholipid syndrome. Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16
  • lupus
    Catastrophic antiphospholipid syndrome causes widespread thrombosis of the microcirculation. Recent aggressive treatments have achieved reductions in mortality from CAPS. Bazzan M, Vaccarino A, and Marletto F. Systemic lupus erythematosus and thrombosis. Thrombosis Journal 2015; 13:16

The risk for developing a thrombotic event is higher in systemic lupus erythematosus (SLE) patients, according to a new systematic review. The authors outline the pathophysiologic and clinical connections between thrombosis and SLE, and provide guidelines on how to treat the intersection of these two diseases.

These slides briefly summarize the main points in the review. You can click through to full text of the review via the hyperlinks to the article title in the captions to each slide.

Source: 
Rheumatology Network

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