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Pyoderma Gangrenosum Fails Initial Treatment Plans

Pyoderma Gangrenosum Fails Initial Treatment Plans

  • Pyoderma gangrenosum (©UBMMedicaLLC). Photo by Irina Litvin, D.O
    Pyoderma gangrenosum (©UBMMedicaLLC). Photo by Irina Litvin, D.O
  • Pyoderma gangrenosum (©UBMMedicaLLC). Photo by Irina Litvin, D.O
    Pyoderma gangrenosum (©UBMMedicaLLC). Photo by Irina Litvin, D.O
  • Pyoderma gangrenosum (©UBMMedicaLLC). Photo by Irina Litvin, D.O
    Pyoderma gangrenosum (©UBMMedicaLLC). Photo by Irina Litvin, D.O

In these images, we feature a case of pyoderma gangrenosum that failed antibiotics, steroids, other immunosuppressive agents, thalidomide and cyclosporinePyoderma gangrenosum is a rare skin ulcer with a pathogenesis that is not yet fully understood, although it is believed to have an immune-related connection. It is frequently associated with rheumatic diseases, inflammatory bowel diseases(IBDs), and endocrine and hematologic disorders.

It often responds to systemic corticosteroid therapy, but in this case, it did not. This patient lived with the condition for years, until a successful round of active IVIG treatment. Her immune response has been described as "remarkable."
 
 
References: 
Angela Ehling, Sigrid Karrer, et al. "Therapeutic Management of Pyoderma Gangrenosum," Arthritis and Rheumatism. Oct. 8, 2004. DOI 10.1002/art.20559 
 
Finja Jockenhofer, Katharina Herberger, et al. "Tricenter analysis of cofactors and comorbidity in patients with pyoderma gangrenosum," JDDG. Oct. 21, 2016. DOI: 10.1111/ddg.12791 
 
 

Comments

how did she get it on the other leg too?

Lynn @

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