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A 27-year-old white man, an active-duty soldier who previously had been healthy, presented with a 5-month history of progressively worsening swelling, pain and, eventually, skin hardening in both legs and then arms

Raynaud phenomenon, joint pain, muscle weakness, and hand discoloration: What is the diagnosis?

A mildly painful, swollen, discolored toe troubled a young woman in midwinter. Small pruritic lesions had appeared and resolved in recent months.

A healthy 40-year-old active-duty male soldier presented with a painless groin mass, which he had noted a few weeks earlier.

A 49-year-old African American man was referred to rheumatology with a positive antinuclear antibodies (ANA) test result, constitutional symptoms, and lymphadenopathy.

A 46-year-old African American woman was admitted with a 3-month history of extensive macular, nonpruritic, erythematous rash on her upper chest wall.

A 17-year-old boy presented with a 3-day history of left upper quadrant abdominal pain; intermittent pain radiated to the right side. The patient complained of nonbilious vomiting and nausea and reported subjective fever. He also had a decreased appetite and up to 10 daily bouts of nonmucoid diarrhea.


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